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caca níqueis de futebol | jogos caça-níqueis grátis antigos

Neurodevelopmental Programming of Adiposity: Contributions to Obesity Risk
Alicja A Skowronski and others
This review analyzes the published evidence regarding maternal factors that influence the developmental programming of long-term adiposity in humans and animals via the central nervous system (CNS). We describe the physiological outcomes of perinatal underfeeding and overfeeding and explore potential mechanisms that may ...
Diabetes Mellitus, Energy Metabolism, and COVID-19
Caterina Conte and others
Obesity, diabetes mellitus (mostly type 2), and COVID-19 show mutual interactions because they are not only risk factors for both acute and chronic COVID-19 manifestations, but also because COVID-19 alters energy metabolism. Such metabolic alterations can lead to dysglycemia and long-lasting effects. Thus, the COVID-19 ...
Protective Factors and the Pathogenesis of Complications in Diabetes
Marc Gregory Yu and others
Chronic complications of diabetes are due to myriad disorders of numerous metabolic pathways that are responsible for most of the morbidity and mortality associated with the disease. Traditionally, diabetes complications are divided into those of microvascular and macrovascular origin. We suggest revising this antiquated ...
Metformin, Cognitive Function, and Changes in the Gut Microbiome
Marisel Rosell-Díaz and José Manuel Fernández-Real
The decline in cognitive function and the prevalence of neurodegenerative disorders are among the most serious threats to health in old age. The prevalence of dementia has reached 50 million people worldwide and has become a major public health problem. The causes of age-related cognitive impairment are multiple, complex, ...
Obesity-Related Hypogonadism in Women
Pei Chia Eng and others
Obesity-related hypogonadotropic hypogonadism is a well-characterized condition in men (termed male obesity-related secondary hypogonadism; MOSH); however, an equivalent condition has not been as clearly described in women. The prevalence of polycystic ovary syndrome (PCOS) is known to increase with obesity, but PCOS is ...
Adipose Tissue Dysfunction and Energy Balance Paradigms in People Living With HIV
Claudia E Ramirez Bustamante and others
Over the past 4 decades, the clinical care of people living with HIV (PLWH) evolved from treatment of acute opportunistic infections to the management of chronic, noncommunicable comorbidities. Concurrently, our understanding of adipose tissue function matured to acknowledge its important endocrine contributions to energy ...
Treating Primary Aldosteronism-Induced Hypertension: Novel Approaches and Future Outlooks
Nathan Mullen and others
Primary aldosteronism (PA) is the most common cause of secondary hypertension and is associated with increased morbidity and mortality when compared with blood pressure–matched cases of primary hypertension. Current limitations in patient care stem from delayed recognition of the condition, limited access to key diagnostic ...
The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B
Bijal Patel and others
Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) neuronal activity and pulsatile GnRH secretion. Their critical role in reproductive health was first identified after inactivating variants in genes ...
Crosstalk Between the Neuroendocrine System and Bone Homeostasis
Yuhu Zhao and others
The caca níqueis de futebol | jogos caça-níqueis grátis antigosostasis of bone microenvironment is the foundation of bone health and comprises 2 concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In the early 21st century, leptin, an adipocytes-derived hormone, was found to affect bone caca níqueis de futebol | jogos caça-níqueis grátis antigosostasis through hypothalamic relay and the sympathetic ...
Radiation-Related Thyroid Cancer
Vladimir Saenko and Norisato Mitsutake
Radiation is an environmental factor that elevates the risk of developing thyroid cancer. Actual and possible scenarios of exposures to external and internal radiation are multiple and diverse. This article reviews radiation doses to the thyroid and corresponding cancer risks due to planned, existing, and emergency ...

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